[摘 要]：目的：通過體外檢測美寶胃腸膠囊（GIC）對胚胎小白鼠小腸器官型植塊生長的作用以探索GIC修復粘膜損傷的機理。方法：體外培養(yǎng)胚胎小白鼠小腸器官型植塊，并將所有植塊分為兩組：實驗組和對照組。結果：實驗組的小腸器官型植塊能很好地維持存活，并有大量的單個細胞、細胞克隆以及片狀粘膜組織塊長出，生長的時間長，生長狀態(tài)好；而對照組的小腸器官型植塊均很快歸于死亡。二者差異極為顯著。結論：GIC能夠維持胚胎小白鼠小腸器官型植塊的存活，并能促進細胞增殖，某種程度上維持組織的完整性，重新組合成粘膜組織，此結果可能與GIC激活上皮干細胞有關。

[關鍵詞]：GIC；小腸植塊；生長

GIC Could Maintain Survival and Promote Cell Growth of Organ-Type Explants of Intestine of Mouse Embryo Xu rong-xiang,Wang Yan-ping,Fan Ran,etc。

Central laboratory, MEBO Global Group 100053

[Abstract]：
Objective: To research on the reparative mechanism of GIC on intestinal lesion through examining the effect of on the survival and cell growth of organ-type explants of intestinal tissue of mouse embryo.
Methods: Cultured the organ-type explants of mouse intestinal tissue in vitro, all the explants were divided into two groups: test group and control group.
Results: Explants could survive in test group. Single cells, cell clones and tissue pieces could grew out of the explants and grew long and well　in test group. Conclusion: could maintain survival of intestinal explants and promote growth of cells from intestinal explants of mouse embryo and this process may be involved in the activation of epithelial stem cells.

[Key words]： GIC; intestinal explant ;　growth

大量臨床實踐顯示，GIC可能也是通過激活粘膜上皮干細胞、促進組織細胞生長的機理實現(xiàn)對損傷粘膜修復的，為了證明這一觀點，我們特設計了本實驗。

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