[摘要]：目的：通過體外檢測美寶胃腸膠囊（GIC）對胚胎小白鼠胃組織器官型植塊生長的影響以探索GIC修復(fù)胃腸道粘膜損傷的機(jī)理。方法：體外培養(yǎng)胚胎小白鼠胃器官型植塊，將植塊分為兩組：實(shí)驗(yàn)組和對照組。結(jié)果：實(shí)驗(yàn)組的胃器官型植塊能很好地維持存活，從其中長出的單個(gè)細(xì)胞以及細(xì)胞克隆生長好、生長時(shí)間長。而對照組的胃器官型植塊很快變性死亡。二者差異非常顯著。結(jié)論：GIC能維持胚胎小白鼠胃器官型植塊存活并促進(jìn)來自植塊的細(xì)胞和細(xì)胞克隆的生長，并且此過程可能與GIC激活上皮干細(xì)胞有關(guān)。

[關(guān)鍵詞]：GIC；胃植塊；生長

GIC Could Maintain Survival and Promote Cell Growth of Organ-Type Explants of Stomach of Mouse Embryo Xu rong-xiang,Wang Yan-ping,Fan Ran,etc。

Central laboratory, MEBO Global Group 100053

[Abstract]： Objective: To research on the reparative mechanism of GIC on the lesion of gastrointestinal tract through testing the effect of GIC on survival and growth of organ-type explants of gastric tissue of mouse embryo. Methods: Cultured the organ-type explants of gastric tissue of mouse embryo in vitro, all the explants were divided into two groups: test group and control group. Results: Explants in test group could survive，single cells and cell clones from explants grew well and long. However, explants, cells and cell clones in control group died off after a short period of time. There was significant difference between two groups. Conclusion: MEBO could promote survival and growth of cells of gastric explants of mouse embryo and this process may be related to activation of epithelial stem cells.

[Key words]： GIC; gastric explant; growth

本實(shí)驗(yàn)的目的在于通過體外檢測GIC對胚胎小白鼠胃組織器官型植塊生長的影響以初步探討GIC治療粘膜損傷性疾病的機(jī)理。

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